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KMID : 0358419960390081507
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Korean Journal of Obstetrics and Gynecology
1996 Volume.39 No. 8 p.1507 ~ p.1511
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The Efficacy of Neoadjuvant Chemotherapy followed by Radical Hysterectomy for Squamous Cell Carcinoma of the Uterine Cervix
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최안나
이규완/이상희/최준식/김해중/구병삼
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Abstract
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Two courses of chemotherapy containing cisplatin, mitomycin and bleomycin as a neoadjuvant treatment was given twenty seven patients with previously untreated bulky(designated as≥3cm size) FIGO stage I b-IIa squamous cell carcinoma of uterine
cervix
and followed by radical surgery.
After chemotherapy responses were detected in 19 patients(6 complate and 13 partial : overall 70.4%).
Surgery consisted of radical hysteretomy plus bilateral lymphadenectomy.
Surgery was performed without significant difficulty.
At histologic examination, complete responses were found in 2(7.4%0 and partial responses in 17(63.0%) cases.
Only one patients had lymph node metastasis(3.8%) and received postoperative radiation therapy. A lower than expected incidence of lymph node metastasis after chemotherapy was detected.
A chemotherapy induced toxicity was mainly represented by nausea and vomiting. There was no grade 4 toxicity noted. Chemotherapy did not increased surgery related complication. Twenty four months median following time has been reached and four
recurrences have been detected so far.
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KEYWORD
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